[ Vol. 1 No. 3 ] (September - December 2000 )
Balanced Administration of Amino Acids in Patients with Chronic Renal Insufficiency

TW Chen, SP Kune*, TP Huang, WY Lui* Nephrology
Department of medicine, Gemeral Surgery*, Taipei - VGH, National Yang ming University, Taipei, Taiwan, R.O.C.


Patients with chronic renal insufficiency are often undernourished. In addition to adequate calorie intake, specific requirements of amino acid for patients with renal insufficiency must be seriously taken into account. Traditionally, the essential amino acids (EAA) are administrated. Plasma imbalance of amino acid is thus frequently found in human body due to inappropriate administration of EAA and non-essential amino acids (NEAA). In this study, we used proportional formula of amino acid solution (Nephrosteril, 7% L-amino acid, EAA:NEAA = 6:4)  to  study  12  chronic  renal  insufficient  patients. These  patients  received  3-day diet control of 35 Kcal/kg/day. Pre-infusion blood samples were taken.  Nephrosteril (0.5 gm AA/kg/day) + restriction oral diet (0.5 gm protein/kg/day) was then infused for 5 days. Post-infusion blood samples were taken as well. The results revealed no change in the profile of amino acids (22 amino acids), especially in lysine, threonine, and histidine. Amino acids of phenylalanine & methionine did not show unbalanced after infusion. The biochemical data did not change due to short time of infusion. In conclusion, infusion of Nephrosteril can maintain balanced amino acids in patients with chronic renal insufficiency.